CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Germline CTLA-4 deficiency causes Front Selector Housing severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells.Cancer patients with severe immune-related adverse events (irAE) after receiving anti-CTLA-4/PD-1 c